D-129
2026-04-17
Symposium
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September 06 (Sun)
09:35-11:30Symposium 01. Joint Session of the Indian Academy of Neuroscience (IAN)-KSBNS: Neurodevelopment and Neurodevelopmenetal DisordersRoom 101-102 -
Neurodevelopmental disorders (NDDs), including autism, intellectual disability, and epilepsy, arise from perturbations in early brain development and constitute a major public health challenge. Although numerous genetic risk factors have been identified, defining the convergent mechanisms underlying their pathobiology remains difficult and continues to impede the development of targeted therapies. This session will integrate emerging genetic discoveries with advances in neurodevelopmental and therapeutic research, providing a focused examination of molecular, cellular, and circuit-level vulnerabilities to genetic and environmental influences. It will further strengthen India–Korea collaboration across genetics, functional genomics, developmental neurobiology, RNA biology, and stem cell biology.
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OrganizerKi-Jun Yoon (Korea Advanced Institute of Science and Technology)
Sourav Banerjee (National Brain Research Centre)
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ModeratorKi-Jun Yoon (Korea Advanced Institute of Science and Technology)
Sourav Banerjee (National Brain Research Centre)
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Speaker
Mechanistic insights gained on cerebral hemisphere formation through advanced imaging tools
Jonaki Sen (Indian Institute of Technology Kanpur)
Brain-wide spontaneous activity in mouse models of autism
Sourav Banerjee (National Brain Research Centre)
Investigating human microcephaly and brain developmental timing using stem cell-derived models
Ki-Jun Yoon (Korea Advanced Institute of Science and Technology)
m6A RNA methylation prevents microcephaly by restricting mitochondrial activation during early human neurodevelopment
Yong Jun Kim (Kyung Hee University)
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September 06 (Sun)
09:35-11:30Symposium 02. Presynaptic Structural Proteins as a Regulator of Short-term Synaptic PlasticityRoom 105-106 -
Synaptic vesicle fusion is preceded by complicated steps that regulate short-term synaptic plasticity, which include recruitment of synaptic vesicles to the active zone, vesicle docking and priming. Recent advances in the presynaptic research elucidated the ultra-structural correlates to these steps, and revolutionized previous concepts of presynaptic processes culminating in synaptic vesicle release. Presynaptic structural proteins and their upstream signaling molecules regulate the functional and spatial organization of pre-docked and docked synaptic vesicles. In this symposium, we would like to focus and share recent key findings on the role of presynaptic structural proteins in short-term synaptic plasticity.
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OrganizerSuk-Ho Lee (Seoul National University)
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ModeratorSuk-Ho Lee (Seoul National University)
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Speaker
A novel actin-based mechanism of post-tetanic potentiation
Seungbok Lee (Seoul National University)
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Actin- and condensate-dependent confinement of synaptic vesicles governs their rapid recruitment for sustained neurotransmission
Takafumi Miki (Akita University)
Liquid–liquid phase separation–mediated presynaptic assembly and its implications for synaptic function
Daehun Park (Catholic University)
CASKIN2 mediates PTPσ-dependent transsynaptic signaling at excitatory synapse
Kyung Ah Han (Chungnam National University)
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September 06 (Sun)
09:35-11:30Symposium 03. Brain–Immune–CSF Networks: New Frontiers in Neural HomeostasisRoom 107-108 -
This symposium will present cutting-edge discoveries uncovering how the brain, immune system, and cerebrospinal fluid (CSF) form integrated networks to sustain neural homeostasis. Distinguished speakers— Takahiro Masuda (Kyushu University), Won-Suk Chung and Gou Young Koh (IBS, KAIST), Andrew Yang (UCSF), and Steven Proulx (University of Bern)—will share new insights into brain vascular and lymphatic pathways mediating waste clearance, immune surveillance and cellular cross-talk with the central nervous system. Together, these studies will reveal new principles of brain–immune–CSF communication in health, aging, and disease.
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OrganizerWon-Suk Chung (Institute for Basic Science/Korea Advanced Institute of Science and Technology)
Gou Young Koh (Institute for Basic Science/Korea Advanced Institute of Science and Technology)
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ModeratorWon-Suk Chung (Institute for Basic Science/Korea Advanced Institute of Science and Technology)
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Speaker
Targeting diverse brain macrophages
Takahiro Masuda (Kyushu University)
Decoding blood and brain crosstalk
Andrew Yang (University of California, San Francisco)
Innate immune roles of glial cells in neurodegeneration
Won-Suk Chung (Institute for Basic Science/Korea Advanced Institute of Science and Technology)
Fluid dynamics and lymphatic outflow in the central nervous system
Steven Proulx (University of Bern)
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September 06 (Sun)
09:35-11:30Symposium 04. Novel Technologies for Monitoring Chemical Neurotransmission/NeuromodulationConference Hall -
Explore cutting-edge technologies revolutionizing neurotransmitter monitoring at this interdisciplinary symposium. Leading researchers will present breakthroughs in real-time detection methods including advanced nanosensors, optogenetic tools, and electrochemical probes for tracking dopamine, serotonin, and other neuromodulators. Topics span from single-molecule sensitivity to in vivo brain imaging, offering insights into neural signaling dynamics critical for understanding brain function and developing neurotherapeutics.
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OrganizerSanghwa Jeong (Pusan National University)
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ModeratorKwang Lee (Daegu Gyeongbuk Institute of Science and Technology)
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Speaker
Spying on neuromodulator dynamics in vivo by constructing multi-color GRABsensors
Yulong Li (Peking University)
Visualizing norepinephrine and beyond: advanced GRAB sensors illuminateneuromodulators in vivo
Jiesi Feng (Peking University)
Multifunctional photometry technique with high SNR
Kwang Lee (Daegu Gyeongbuk Institute of Science and Technology)
Systematic selection of near-infrared optical nanoprobes for realtimeneurochemical imaging
Sanghwa Jeong (Pusan National University)
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September 06 (Sun)
12:30-14:25Symposium 05. When Brain Meets Immune System: Exploring New Avenues of Neuro-Immune InteractionRoom 101-102 -
Once regarded as immune privileged, the brain is now recognized as part of a dynamic ecosystem in constant dialogue with the immune system. This symposium, When Brain Meets Immune System: Exploring New Avenues of Neuro-Immune Interaction, brings together leading researchers to discuss how immune signals shape neural development, circuit function, and behavior. By highlighting recent advances that bridge neuroscience and immunology, the session underscores a paradigm shift, viewing the brain not as an isolated organ but as a central node within a body-wide network that maintains health, influences disease, and guides social and cognitive function.
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OrganizerEunha Kim (Korea University)
Je-Min Choi (Hanyang University)
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ModeratorJe-Min Choi (Hanyang University)
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Speaker
Neuroimmune interactions shaping social behavior
Anna Victoria Molofsky (University of California, San Francisco)
Astrocyte epigenetic memory promotes CNS inflammation
Hong-Gyun Lee (Seoul National University)
Early-life brain-resident Tregs establish lifelong CNS immune niche and synaptic homeostasis
Ho-Keun Kwon (Yonsei University)
In vivo CAR-based therapy for neurodegenerative diseases
Hyungseok Seo (Seoul National University)
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September 06 (Sun)
12:30-14:25Symposium 06. Glia–Neuron Interactions in Shaping Neural CircuitsRoom 103-104 -
Glial cells are increasingly recognized as active participants in sculpting neural circuit architecture, yet their precise contributions to circuit development and function remain incompletely understood. This symposium will highlight cutting-edge research that uncovers novel mechanisms by which glia–neuron interactions shape synaptic connectivity, plasticity, and behaviorally relevant circuits. Four distinguished speakers will present recent discoveries using state-of-the-art approaches, including advanced imaging, mouse genetics, optogenetics, and electrophysiology, to reveal how astrocytes and other glial populations instruct neuronal wiring and adaptability. By bridging cellular and circuit-level insights, this symposium offers a compelling narrative for audiences interested in neuroscience, glial biology, and translational approaches to brain disorders.
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OrganizerJi Won Um (Daegu Gyeongbuk Institute of Science and Technology)
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ModeratorJi Won Um (Daegu Gyeongbuk Institute of Science and Technology)
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Speaker
Astrocyte regulation of synapse formation and function
Nicola J. Allen (Salk Institute for Biological Studies)
The contribution of glial cells to the pathophysiology of emotion disorders
Jie Tu (Chinese Academy of Sciences)
Thalamic glial network tunes the sensory processing
Eunji Cheong (Yonsei University)
Replacing microglia to treat a brain disease
Yongjin Yoo (Korea University)
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September 06 (Sun)
12:30-14:25Symposium 07. Connectomics for Mapping Circuit Structure to FunctionRoom 105-106 -
Connectomics using electron microscopy (EM) volume imaging provides synapse-level wiring diagrams of nervous systems. Such connectome data are now available for the entire nervous systems of C. elegans and Drosophila melanogaster, and partially for the mouse and other vertebrate species. However, inferring neural functions from these wiring diagrams remains a major challenge. In this symposium, speakers will present their latest work on connectome analyses (Hyeyoung Shin, SNU), comparative connectomics (Alexander J. Bae, KAIST), connectome-based investigations of neural circuits underlying feeding behavior (Jinseop Kim, SKKU) and spatial navigation (Sung Soo Kim, UCSB), highlighting the breadth of research efforts that use connectomes to infer neural functions. This symposium will showcase exciting research on connectomics and its applications to understanding neural functions and behavior.
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OrganizerAnmo Kim (Hanyang University)
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ModeratorAnmo Kim (Hanyang University)
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Speaker
Comparative connectomics reveals neural circuits underlying stage-specific behaviors
Alexander J. Bae (Korea Advanced Institute of Science and Technology)
Distance, synaptic in-degree and out-degree govern higher-order connectivity and neocortical dynamics
Hyeyoung Shin (Seoul National University)
Neural circuits of multi-sensory integration for feeding behavior in Drosophila
Jinseop Kim (Sunkyunkwan University)
Vector coordinate transformation in the fly navigation system
Sung Soo Kim (University of California, Santa Barbara)
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September 06 (Sun)
12:30-14:25Symposium 08. Neuroscience-Driven Non-Human Primate Brain–Machine Interface (BMI) Research for the Emerging Neuro-IndustryRoom 107-108 -
This symposium highlights neuroscience-based brain–machine interface (BMI) research in non-human primates (NHPs). Prof. Kyung-In Jang introduces soft, biocompatible implants enabling long-term stable interfacing (NHP BMI recording system). Prof. Seung-Woo Lee presents decoding and stimulation systems for cognitive rehabilitation (NHP BMI stimulation system). Prof. Yiwen Wang will discuss recent advances in neuronal population decoding for intracortical BMIs (NHP BMI decoding system). Prof. Jeong-Woo Sohn demonstrates neural information injection into the brain to guide decision-making, revealing fundamental neural principles of choice behavior (NHP BMI decision-making system). Together, they emphasize how NHP neuroscience drives translational neuro-industrial innovation.
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OrganizerHyoung F. Kim (Seoul National University)
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ModeratorJoonyeol Lee (Sunkyunkwan University)
Hyoung F. Kim (Seoul National University)
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Speaker
Injecting neural information to modulate decision-making: from non-human primates to brain–machine interfaces
Jeong-Woo Sohn (Catholic Kwandong University)
Stealthy neural recorder for studying natura behavior in primate models
Kyung-In Jang (Daegu Gyeongbuk Institute of Science and Technology/ENSIDE Corp.)
Neuronal population decoding for intracortical brain-machine interfaces
Yiwen Wang (The Hong Kong University of Science and Technology)
High-resolution brain-computer interfaces for vision restoration
Seung Woo Lee (Korea Advanced Institute of Science and Technology)
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September 07 (Mon)
08:30-10:25Symposium 09. Evo-NeuroDevo: A Comparative View of Mammalian Brain DevelopmentRoom 101-102 -
Understanding how human brain is special is one of the ultimate goals of neuroscience. Comparative studies across mammals therefore provide crucial insights into both human-specific or evolutionarily conserved developmental processes and cell lineages. This symposium will explore evolutionary aspects of mammalian brain development by integrating findings from humans, mice, marmosets and gyrencephalic animals such as ferrets and pigs, revealing key developmental innovations that distinguish the human brain. By bridging multiple experimental systems and evolutionary perspectives, this session aims to highlight how comparative neurodevelopmental approaches can illuminate what makes the human brain unique.
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OrganizerChanguk Chung (Korea Advanced Institute of Science and Technology)
Kihoon Han (Korea University)
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ModeratorChanguk Chung (Korea Advanced Institute of Science and Technology)
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Speaker
Elucidating the molecular mechanisms of brain development through the integration of human brain organoids and mouse models
Jinju Han (Korea Advanced Institute of Science and Technology)
Investigation of the mechanisms underlying the development and evolution of the brain using gyrencephalic ferrets
Hiroshi Kawasaki (Kanazawa University)
Protracted migration of cortical inhibitory neurons for the complexity of higher cognitive areas
JaeYeon Kim (University of California, San Francisco)
Convergent emergence of robust pallial circuits underlying advanced intelligence
Song-Hai Shi (Tsinghua University)
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September 07 (Mon)
09:35-11:30Symposium 10. Peptidergic & Dopaminergic Reprogramming of Affective and Compulsive BehaviorsRoom 103-104 -
This symposium explores the reprogramming of peptidergic and dopaminergic neural circuits underlying affective, stress-related, and compulsive behaviors. Speakers will present cutting-edge research integrating translatomic and circuit-level analyses, focusing on: 1) The central role of Drd2/insulin signaling in amygdala-driven compulsion, and 2) Novel peptidergic pathways influencing panic/stress and antidepressant response. Leveraging advanced modulation technologies, the session's novelty is in revealing precise neuromodulation targets for psychiatric and metabolic disorders, offering broad appeal to translational neuroscience audiences.
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OrganizerKwang Lee (Daegu Gyeongbuk Institute of Science and Technology)
Yong-Seok Oh (Daegu Gyeongbuk Institute of Science and Technology)
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ModeratorKwang Lee (Daegu Gyeongbuk Institute of Science and Technology)
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Speaker
Targeting brain dopamine–insulin interaction: toward new strategies for compulsive and addictive behaviors
Ja-Hyun Baik (Korea University)
Probing neuromodulatory control of affective behaviors with presynaptic silencers
Sung Han (Salk Institute of Biological Studies)
iTango-Launcher -Drd2: Drd2-specific neural circuit modulation
Dongmin Lee (Korea University)
Translational reprogramming of peptidergic circuitry gating antidepressant efficacy
Yong-Seok Oh (Daegu Gyeongbuk Institute of Science and Technology)
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September 07 (Mon)
08:30-10:25Symposium 11. Higher-Order Cognitive Processes: Integrating Mechanism, Representation, and ComputationRoom 105-106 -
In this symposium, we aim to examine and discuss higher-order cognitive processes—such as human awareness, abstraction, and imagery—from multiple perspectives, ranging from synaptic mechanisms to network- and whole-brain-level dynamics. The talks will cover research on synaptic plasticity rules that enable higher cognitive functions, studies on high-level perception including metacognitive awareness and abstraction, and work on internally generated mental content such as visual imagery. In addition, we will discuss large brain models that build on these fundamental findings. By bringing these perspectives together, we hope to explore how higher-order cognitive processes operate across different levels and content domains.
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OrganizerSue-Hyun Lee (Seoul National University)
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ModeratorSue-Hyun Lee (Seoul National University)
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Speaker
Synaptic plasticity rules that enable modeling higher cognitive functions
Tomoki Fukai (Okinawa Institute of Science and Technology)
Decoding mental content from human brain activity via deep neural network representations
Tomoyasu Horikawa (Communication Science Laboratories, NTT Inc.)
The roles of the lateral prefrontal cortex in visual cognition?
Hakwan Lau (Institute for Basic Science)
Large brain model
Jiook Cha (Seoul National University)
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September 07 (Mon)
08:30-10:25Symposium 12. Chronic Pain: Clinical Unmet Needs to Novel Target and TherapeuticsRoom 107-108 -
Chronic pain remains a critical challenge where bench-side discoveries often fail to translate into effective therapies. This symposium addresses the translational gap by integrating clinical insights with mechanistic innovation. We begin by examining barriers that prevent preclinical findings from achieving clinical success. Next, we present novel molecular targets, including maladaptive mGluR signaling and NPTX2-dependent synaptic plasticity. Finally, we showcase next-generation therapeutics, from repurposing psychedelics to engineering photocontrolled CRISPR for spatially precise gene regulation. This session provides a strategic roadmap for transforming discoveries into viable pain therapeutics.
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OrganizerJihye Seong (Seoul National University)
Sang Jeong Kim (Seoul National University)
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ModeratorJihye Seong (Seoul National University)
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Speaker
Exploring why benchside discoveries struggle to translate into clinical practice in chronic pain
Jee Youn Moon (Seoul National University Hospital)
Maladaptation of metabotropic glutamate receptor signaling in chronic neuropathic pain
Sang Jeong Kim (Seoul National University)
Harnessing NPTX2-dependent plasticity for long-lasting pain relief via psychedelic Ibogaine
Seung-Eon Roh (Johns Hopkins University)
Engineering of photocontrolled CRISPR proteins for spatially targeted gene editing in the nervous system
Michael Z. Lin (Stanford University)
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September 07 (Mon)
08:30-10:25Symposium 13. Minds Meet Machines: Bidirectional Innovations in AI and NeuroscienceConference Hall -
This symposium explores the bidirectional exchange of ideas between neuroscience and AI, highlighting how brain-inspired computational models and neural circuit mechanisms can drive new advances in machine learning, while AI-based analytical tools provide deeper insights into neural dynamics and behavior. The talks span hippocampal computation, prefrontal and cerebellar circuit functions, collective neural dynamics, and AI-driven modeling frameworks. By integrating experimental and computational perspectives, the symposium aims to reveal unifying principles of intelligence and promote cross-disciplinary innovation within a broad neuroscience audience.
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OrganizerJea Kwon (Max Planck Institute for Security and Privacy)
Sunpil Kim (Institute for Basic Science)
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ModeratorJea Kwon (Max Planck Institute for Security and Privacy)
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Speaker
Decoding collective behavior through neural dynamics and AI
Jee Hyun Choi (Korea Institute of Science and Technology)
Hippocampal model of generalization with memory-resilient cognitive maps
Jaedong Hwang (Massachusetts Institute of Technology)
Neural computations underlying paradoxical belief reinforcement from a single conflict
Minsu Abel Yang (Korea Advanced Institute of Science and Technology)
Cerebellar computations for flexible control of movements
Sungho Hong (Institute for Basic Science)
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September 07 (Mon)
11:10-12:50Symposium 14. Mechanisms and Therapeutic Targets for Neurodevelopmental Dysfunction in Brain DisordersRoom 101-102 -
This symposium brings together leading researchers investigating how genetic mutations disrupt neurodevelopmental processes across molecular, cellular, and circuit levels. Speakers will present new insights from cutting-edge approaches, including single-cell and multi-omics analyses, advanced mouse and primate models, human organoids, and translational studies. By integrating mechanisms of synaptic, neuronal, and circuit dysfunction with therapeutic strategies, the session will appeal to a broad neuroscience audience.
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OrganizerEunjoon Kim (Institute for Basic Science/Korea Advanced Institute of Science and Technology)
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ModeratorEunjoon Kim (Institute for Basic Science/Korea Advanced Institute of Science and Technology)
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Speaker
Molecular, cellular, and functional signatures of NDD associated mutation in the brain
Joseph Dougherty (Washington University in St. Louise)
Dysregulated translation in mouse and human models of neurodevelopmental disorders
Eric Klann (New York University)
Modeling neurodevelopmental disorders to understand the pathophysiology
Toru Takumi (Kobe University)
New methods to address neurodevelopmental deficits in Shank2 and Shank3 models of autism
Mihyun Bae (Institute for Basic Science)
Remapping social stress with empathy-driven social buffering
Hyoseon Oh (Icahn School of Medicine at Mount Sinai)
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September 07 (Mon)
11:10-12:50Symposium 15. Brain Barriers in Health and DiseaseRoom 103-104 -
The brain barrier—comprising endothelial cells, pericytes, and astrocytic endfeet within the neurovascular unit—regulates molecular exchange between the periphery and CNS. Endothelial energy metabolism is vital for maintaining its integrity, and metabolic dysfunction drives blood–brain barrier (BBB) breakdown in acute and chronic brain injury. Such disruption worsens edema and inflammation and limits therapeutic delivery. Yet, no defined diagnostics or treatments exist to restore BBB integrity. This session gathers neuroscientists and translational researchers to explore mechanisms linking endothelial metabolism and BBB stability, identify molecular targets for repair, and assess non-invasive strategies such as electrical /optical stimulation to reversibly modulate barrier permeability.
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OrganizerJun young Heo (Chungnam National University)
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ModeratorJun young Heo (Chungnam National University)
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Speaker
Endothelial Wnt/β-catenin signaling regulates the BBB in systemic inflammation
Jun Lei Chang (Jilin University)
Brain endothelial ASM-dependent gut–brain immune circuit links stress to depression
Hee Kyung Jin (Kyungpook National University)
Brain stimulation approaches for neurovascular dysfunction: research and therapeutic applications
Hwa Kyoung Shin (Pusan National University)
Mapping the luminal surface proteome of the blood-brain barrier by proximity labeling
Jongshin Kim (Pohang University of Science and Technology)
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September 07 (Mon)
11:10-12:50Symposium 16. Integrative Perspectives on Neural Plasticity Dynamics and Long-Term Memory Maintenance MechanismsRoom 105-106 -
Recent advances in neuroscience have revealed much about how memories are formed and stored, yet how they are stably maintained throughout life remains elusive. Understanding this requires not only technological innovation but also new conceptual frameworks that link the molecular and synaptic events leading to plastic changes in dendrites with the large-scale network dynamics underlying memory consolidation. This symposium brings together leading systems neuroscientists who investigate the mechanisms of memory formation and persistence using cutting-edge approaches such as calcium and voltage imaging, molecular and chemical techniques, in vivo multichannel electrophysiology, and optogenetic modulation of neural plasticity. By combining these state-of-the-art tools with novel hypotheses about how the brain preserves memory traces, the symposium aims to provide an integrated and forward-looking view of the mechanisms underlying lifelong memory.
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OrganizerAin Chung (Korea Advanced Institute of Science and Technology)
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ModeratorAin Chung (Korea Advanced Institute of Science and Technology)
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Speaker
Reframing memory and plasticity dynamics in cognition
André Fenton (New York University)
Linking functional and structural dendritic spine remodeling during fear learning and extinction in vivo
Cora Lai (The University of Hong Kong)
Optical electrophysiology maps the cellular basis of learning and memory
Pojeong Park (Daegu Gyeongbuk Institute of Science and Technology)
Nonlinear dynamics of motor cortex manifolds during sleep-dependent memory consolidation
Jaekyung Kim (Korea Advanced Institute of Science and Technology)
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September 07 (Mon)
11:10-12:50Symposium 17. Brain–Body Axis: Inter-organ Signaling, Microbiome, and Homeostatic RegulationRoom 107-108 -
This symposium explores how inter-organ signaling and the microbiome shape homeostatic regulation through the brain–body axis. By integrating discoveries from mammalian (mouse) and invertebrate (Drosophila) models, it highlights evolutionarily conserved mechanisms linking gut hormones, autonomic circuits, and metabolic state to behavior. Talks will feature new findings on nutrient dependent gut–brain hormonal pathways, sympathetic control of energy balance, microbiome-derived metabolites driving disease, and gut-hormone–mediated behavioral modulation. Together, these studies illustrate emerging principles of microbiome–neural–metabolic interaction with broad relevance to physiology and disease.
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OrganizerGreg Seong-Bae Suh (Institute for Basic Science/Gwangju Institute of Science and Technology)
Yangkyun Oh (Ewha Womans University)
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ModeratorYangkyun Oh (Ewha Womans University)
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Speaker
Thermosensory regulation of gustatory processing in feeding decisions
Hui-Hao Lin (SUNY Upstate Medical University)
Sympathetic regulation of energy balance
Wenwen Zeng (Tsinghua University)
Colonization of oral microbes in the gut as a driver of Parkinson’s disease
Ara Koh (Pohang University of Science and Technology)
A gut-to-brain hormonal and neuronal pathway mediating physiological changes in Drosophila
Yangkyun Oh (Ewha Womans University)
Peripheral to central transmission of pathogenic a-Synuclein via the gut-brain axis
Byung-Kwon Jung (Institute for Basic Science/Gwangju Institute of Science and Technology)
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September 07 (Mon)
11:10-12:50Symposium 18. Integrative Neuroengineering Approaches for Advancing Brain Monitoring and PredictionConference Hall -
This symposium highlights cutting-edge neuroengineering approaches that bridge computational neuroscience, multimodal neural monitoring, and advanced imaging technologies. Talks feature predictive modeling frameworks for behavior and disease, next-generation imaging for brain and spinal disorders, real-time neurochemical and electrophysiologic monitoring for neurosurgery, and mesoscopic mechanisms of neural computation revealed through EEG rhythms. By integrating engineering innovation with clinical and basic neuroscience, the symposium offers novel perspectives and tools with broad relevance across the neuroscience community.
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OrganizerJae-Ho Han (Korea University)
Hojin Jang (Korea University)
Bo-Yong Park (Korea University)
Yoonbae Oh (Korea University)
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ModeratorBo-Yong Park (Korea University)
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Speaker
A brain-based normative predictive framework for phenotypes and diseases
Kwangsun Yoo (Sungkyunkwan University)
Advances in imaging modalities for pediatric brain and spinal cord tumors
Avner Meoded (Children's Mercy Hospital)
A multimodal platform for real-time neurochemical and electrophysiologic monitoring for intraoperative neurosurgical applications
Kendall H. Lee (Mayo Clinic)
EEG theta rhythms as a mesoscopic mechanism for neural information processing
Hio-Been Han (Seoul National University of Science and Technology)
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September 08 (Tue)
08:50-10:45Symposium 19. The Molecular and Cellular Basis of Sleep Homeostasis across Diverse Model OrganismsRoom 101-102 -
Sleep is a fundamental biological state essential for survival across the animal kingdom, yet the specific cellular signals that track sleep need and drive homeostatic recovery remain as open questions. This symposium will explore the conserved mechanisms that regulate sleep architecture across species. Experts using various model organisms will present cutting-edge research linking mitochondrial dynamics, neuroenergetics, and ion channel function to sleep control. They will further examine how presynaptic release probability and distinct genetic pathways shape the biological demand for sleep. Attendees will gain a comprehensive understanding of the metabolic and synaptic foundations of sleep homeostasis and the evolutionary principles governing sleep regulation.
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OrganizerStaci Jakyong Kim (Korea Advanced Institute of Science and Technology)
Haram Park (University of Oxford)
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ModeratorStaci Jakyong Kim (Korea Advanced Institute of Science and Technology)
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Speaker
Neuroenergetic dynamics of a sleep-control centre
Raffaele Sarnataro (University of Oxford)
Mitochondrial control of non-rapid eye movement sleep
Haram Park (University of Oxford)
Forward genetic screening links sleep regulation to ion channels
Hiromasa Funato (University of Tsukuba)
Presynaptic release probability determines the need for sleep
Sha Liu (VIB-KU Leuven Center for Neuroscience)
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September 08 (Tue)
08:50-10:45Symposium 20. Bidirectional Brain–Clock Dynamics: Regulation and Impact of Circadian Rhythms and SleepRoom 103-104 -
Tremendous progress has been made in uncovering the brain mechanisms that govern circadian rhythms and sleep. At the same time, disruptions in these processes are increasingly linked to neurological and psychiatric disorders, highlighting a bidirectional relationship: the brain regulates circadian rhythms and sleep, while circadian rhythms and sleep are essential for maintaining healthy brain function. Nevertheless, understanding this reciprocal interaction—fundamental to daily life—remains a complex yet critical challenge. This session highlights recent advances in elucidating this two-way relationship, spanning the diverse factors that shape circadian and sleep regulation and the roles of these processes in brain function across molecular, cellular, and network levels.
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OrganizerKeiko Tanaka-Yamamoto (Korea Institute of Science and Technology)
Han Kyoung Choe (Daegu Gyeongbuk Institute of Science and Technology)
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ModeratorKeiko Tanaka-Yamamoto (Korea Institute of Science and Technology)
Han Kyoung Choe (Daegu Gyeongbuk Institute of Science and Technology)
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Speaker
Role of offline LTP in memory consolidation
Yasunori Hayashi (Kyoto University)
Molecular and neural mechanism of homeostatic sleep regulation in mice
Qinghua Liu (National Institute of Biological Sciences)
Master clock-thalamus-medial prefrontal cortex circuit controls circadian social priority
Han Kyoung Choe (Daegu Gyeongbuk Institute of Science and Technology)
PGO waves coordinate brain-wide dynamics across sleep states in mice
Tomomi Tsunematsu (Hokkaido University)
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September 08 (Tue)
08:50-10:45Symposium 21. Decoding Cellular and Immune Landscapes for Precision NeurologyRoom 105-106 -
This symposium will explore how cellular identity, immune function, and genomic variation converge to shape neurological diseases across the lifespan, from neurodegeneration to stroke and rare disorders. By integrating single-cell phenomics, microglial biology, long-read genomics, and immune–stromal remodeling at CNS borders, the speakers will highlight data-driven approaches that bridge basic mechanisms with precision diagnostics and therapeutics.
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OrganizerDohoung Kim (Pohang University of Science and Technology)
Jongshin Kim (Pohang University of Science and Technology)
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ModeratorDohoung Kim (Pohang University of Science and Technology)
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Speaker
Function of microglia in Alzheimer’s disease
Shoutang Wang (The University of Hong Kong)
Decoding cell identity: From phenomics to precision neuro-medicine
Sohyon Lee (Korea Advanced Institute of Science and Technology)
Programmable genomic medicine in rare disease
Jangsup Moon (Seoul National University Hospital)
Immune-stromal crosstalk at CNS borders: macrophage heterogeneity and structural remodeling after stroke
Tae-Ryong Tim Riew (Catholic University)
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September 08 (Tue)
08:50-10:45Symposium 22. Connecting the Dots: Inter-/Intracellular Perspectives to Advance Understanding of NeurodegenerationRoom 107-108 -
Neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), pose pressing challenges to modern aging societies. While numerous studies have advanced our understanding of the causes and progression of AD and PD, novel cellular mechanisms continue to be uncovered as technologies evolve. This symposium will introduce inter- and intracellular mechanisms underlying neurodegenerative diseases using multiscale approaches enabled by state-of-the-art ultrastructural and molecular imaging, and molecular sensing tools. In addition, speakers will present the translational potential of these methodologies.
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OrganizerSeok-Kyu Kwon (Korea Institute of Science and Technology)
Yun Kyung Kim (Korea Institute of Science and Technology)
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ModeratorSeok-Kyu Kwon (Korea Institute of Science and Technology)
Yun Kyung Kim (Korea Institute of Science and Technology)
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Speaker
Mitochondrial dynamics in neuronal health and degeneration
Thomas Schwarz (Harvard University)
Ultrafast endocytosis of synaptic vesicles: its mechanism and implications for neurodegenerative diseases
Shigeki Watanabe (Johns Hopkins University)
Targeting neuroinflammatory response for the treatment of neurodegenerative diseases
Taisuke Tomita (University of Tokyo)
Four-repeat Tau in atypical Parkinsonisms; strategies for combat
Yun Kyung Kim (Korea Institute of Science and Technology)
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September 08 (Tue)
12:40-14:35Symposium 23. Visualizing and Remodeling Cellular Connectivity in the BrainRoom 101-102 -
This symposium will highlight cutting-edge technologies that enable direct visualization and targeted remodeling of cellular connectivity in the brain. Speakers will present nanoscale imaging of non-synaptic communication pathways, super-multicolor circuit mapping, large-scale single-neuron projectome reconstruction across species, and synthetic molecular tools for imaging and editing intercellular interactions. Together, these approaches uncover how neural circuits are structured, how different brain cell types communicate across multiple spatial scales, and how connectivity can be experimentally rewritten. This session will appeal to a broad audience interested in neural structure, function, plasticity, disease mechanisms, and the rapidly emerging technologies transforming modern neuroscience.
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OrganizerSangkyu Lee (Institute for Basic Science)
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ModeratorSangkyu Lee (Institute for Basic Science)
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Speaker
Brain communication by dendritic nanotube network
Hyung-Bae Kwon (Johns Hopkins University School of Medicine)
Optical clearing strategies for studying dynamic neuronal circuits
Takeshi Imai (Kyushu University)
A thalamo-hippocampal circuit regulating memory precision
Chun Xu (Institute of Neuroscience, Chinese Academy of Sciences)
Synthetic molecular approaches to mapping and reshaping brain-cell connectivity
Sangkyu Lee (Institute for Basic Science)
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September 08 (Tue)
12:40-14:35Symposium 24. Architecture and Dynamics of the SynapseRoom 103-104 -
Synapses are highly specialized structures whose architecture and dynamic remodeling are critical for neural circuit function. This symposium will showcase recent advances elucidating how synaptic organization is established, maintained, and reshaped through diverse molecular pathways, including activity-dependent signaling, cytoskeletal remodeling, and protein quality control mechanisms such as ubiquitination. By integrating insights from structural biology, super-resolution imaging, electrophysiology, and molecular genetics, the speakers will highlight cutting-edge discoveries regarding the regulation of synaptic assembly and plasticity in both development and disease. Collectively, these talks will offer a comprehensive perspective on how synaptic architecture and dynamics govern brain function and contribute to neuropsychiatric and neurodegenerative disorders.
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OrganizerJaewon Ko (Daegu Gyeongbuk Institute of Science and Technology)
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ModeratorJaewon Ko (Daegu Gyeongbuk Institute of Science and Technology)
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Speaker
Investigating the roles of adhesion GPCRs in synapse formation and circuit assembly
Richard Sando (Vanderbilt University)
Decoding latrophilin expression in neural and vascular networks
Garret Anderson (University of California, Riverside)
In vivo synapse-specific restoration in SYNJ1-related epileptic encephalopathy
Shawn Je (DUKE-NUS Medical School)
Emerging roles of Trip12, an E3 ubiquitin ligase in autism spectrum disorders
Chunmei Jin (Korea Advanced Institute of Science and Technology/Institute for Basic Science)
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September 08 (Tue)
12:40-14:35Symposium 25. Perceptual Decision Processes across Olfaction, Audition, and VisionRoom 105-106 -
Perceptual decision making involves transforming sensory inputs into perceptual judgements through distributed neural computations. This symposium will highlight systems-level studies that explore how the brain integrates and transforms information across olfactory, auditory, and visual modalities to generate perceptual decisions leading to motor actions. By combining advanced recording, imaging, and circuit-manipulation techniques, the speakers will reveal new computational principles shared or specialized across cortical and subcortical circuits. The session offers a unique cross-modal perspective on perceptual decision making, appealing to broad neuroscientists interested in cognition, sensory processing, and neural computation that form the basis of complex behavior.
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OrganizerDoyun Lee (Institute for Basic Science)
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ModeratorJong Won Lee (Institute for Basic Science)
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Speaker
Distributed neural dynamics underlying sensory-to-motor transformation during olfactory decision making
Doyun Lee (Institute for Basic Science)
Neural circuit computations underlying generalization in auditory decision-making
Ning-long Xu (Chinese Academy of Science)
Frontal area engagement during an olfactory working memory task and task switching
Izumi Fukunaga (Okinawa Institute of Science and Technology)
Hierarchical summary statistics encoding across primary visual and posterior parietal cortices
Yee Joon Kim (Institute for Basic Science)
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September 08 (Tue)
12:40-14:35Symposium 26. Roles of Glycosylation in Brain Function and Disorders: From Pathophysiology to Therapeutic PotentialRoom 107-108 -
Glycosylation, one of the most complex post-translational modifications (PTMs), has been particularly challenging to study in neurological contexts due to its heterogeneous nature and the associated analytical difficulties. However, with advancements in technology in recent years, several studies have highlighted the significant role of glycosylation in normal brain functions, as well as its critical involvement in the pathophysiology of brain disorders, including epilepsy, stroke, and depression. In this session, we have invited leading scientists who are at the forefront of examining the role of glycosylation in brain function and diseases. This is a groundbreaking session, as it represents the first of its kind in the history of KSBNS.
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OrganizerC. Justin Lee (Institute for Basic Science)
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ModeratorC. Justin Lee (Institute for Basic Science)
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Speaker
Development of new NGLY1 assay systems – toward developing an early screeningmethod for NGLY1 deficiency
Tadashi Suzuki (RIKEN)
Medial prefrontal N-glycan dysregulation as a reversible driver of cognitive impairment
Hyun Joo An (Chungnam National University)
Brain somatic mutations in SLC35A2 cause intractable epilepsy with aberrant N-glycosylation
Jeong Ho Lee (Korea Advanced Institute of Science and Technology)
Abnormal glycan sialylation in the mPFC contributes to depressive-like behaviors in mice
Boyoung Lee (Institute for Basic Science)
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September 08 (Tue)
12:40-14:35Symposium 27. The Dynamics of Adenosine Signaling in Brain Health and DiseaseRoom 204-205 -
Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the body as a metabolic intermediary. Adenosine is now increasingly recognized as a key neuromodulator and dynamically regulated in response to ischemia, hypoxia, inflammation and other brain insults. Over the last decade, there are convergence of the structural biology, medicinal chemistry, molecular genetics and pharmacological and epidemiological evidence strongly that the dynamic of adenosine signaling play important roles in homeostasis control of brain functions (including sleep/wakefulness, to cognition and glymphatic activity) and brain disorders (Parkinson’s disease, depression and stroke) and support the proposal that adenosine signaling present important therapeutic targets for controlling brain functions and treatment for various neuropsychiatric disorders. This mini-symposium/review highlights several important development/progress in uncovering critical role of adenosine signaling in a variety of brain functions (such as sleep and glymphatic activity) and brain disorders and treatments (including depression and stroke) with distinct regulatory mechanisms.
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OrganizerJiang-Fan Chen (Wenzhou Medical University)
Tae Kim (Daegu Gyeongbuk Institute of Science and Technology)
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ModeratorJiang-Fan Chen (Wenzhou Medical University)
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Speaker
Adenosine signaling drives antidepressant actions of ketamine and ECT
Minmin Luo (Chinese Institute for Brain Research)
Spatiotemporal orchestration of purinergic signalling in neuron–glia communication
Mike Lazarus (University of Tsukuba)
A non-pharmacological enhancement of NREM sleep by near-infrared photobiomodulation via adenosinergic signaling: evidence from cells, animals, and humans
Tae Kim (Daegu Gyeongbuk Institute of Science and Technology)
40Hz flicker: adenosine hypothesis and translational implication
Jiang-Fan Chen (Wenzhou Medical University)
Spatiotemporal orchestration of purinergic signalling in neuron–glia communication
Eiji Shigetomi (University of Yamanashi)
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September 08 (Tue)
16:05-18:00Symposium 28. Mechanistic Insights into Basal Ganglia Circuits: Synapses, Microglia, and BehaviorConference Hall -
Understanding how the basal ganglia assemble and regulate behavior requires linking defined cell types and pathways to circuit dynamics. This symposium unites complementary advances: thalamo–insular interactions that couple motor and limbic systems and generate tics; neuron–microglia mechanisms that drive alpha-synuclein spread and circuit failure in Parkinson’s disease; dopaminergic control of basal ganglia nuclei, from synaptic modulation to microglia-mediated plasticity; and the activity-dependent assembly of corticostriatal circuits supporting vocalization. Together, causal perturbations with multi-region recordings and imaging reveal principles that connect synapses to circuits to behavior and point to translational strategies for movement disorders.
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OrganizerYu-Wei Wu (Academia Sinica)
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ModeratorMin-Ho Nam (Korea Institute of Science and Technology)
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Speaker
Thalamo-insular pathway regulates tic generation via motor-limbic crosstalk
Yoshihisa Tachibana (Kobe University)
Mechanisms of neuron-microglia alpha-synuclein propagation in Parkinson's disease
Margaret S. Ho (National Yang Ming Chiao Tung University)
Dopaminergic modulation of basal ganglia nuclei: from neuronal synapses to microglia
Jae-Ick Kim (Ulsan National Institute of Science and Technology)
Activity-dependent development of corticostriatal circuits for vocalization in mice
Hsiao-Ying Kuo (National Yang Ming Chiao Tung University)
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September 08 (Tue)
16:05-18:00Symposium 29. Beyond Movement: Emerging Molecular, Circuit, and Functional Insights into the CerebellumRoom 101-102 -
The cerebellum, traditionally associated with motor coordination, is increasingly recognized as a key player in higher-order brain functions. This session showcases cutting-edge research revealing its diverse roles. The first presentation highlights human-specific features of the cerebellum uncovered through cross-species single-nucleus multiomic profiling. The second talk explores new insights into the anatomical organization of cerebellar nonmotor outputs. The third presentation examines regional and cell type–specific transcriptional changes in the cerebellar cortex during auditory fear conditioning. Finally, the last talk presents single-nucleus analyses of the cerebellar cortex in patients with depression, identifying altered cell types and disrupted intercellular communication linked to affective disorders. Together, these studies illuminate the expanding functions of the cerebellum, highlighting its significance beyond motor control.
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OrganizerHyo Jung Kang (Chung-Ang University)
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ModeratorHyo Jung Kang (Chung-Ang University)
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Speaker
Human-specific features of the cerebellum and ZP2-regulated synapse development
Suel-Kee Kim (Yale University)
Anatomical parcellation of cerebellar nonmotor outputs
Hirofumi Fujita (University of Texas Southwestern Medical Center)
Molecular and circuit mechanisms modulating auditory fear conditioning in mice
Yong-Seok Lee (Seoul National University)
Single-nucleus transcriptome network analysis reveals significant alterations in cerebellar-specific intercellular communication in major depressive disorder
Hyo Jung Kang (Chung-Ang University)
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September 08 (Tue)
16:05-18:00Symposium 30. Synapses to Symptoms: PFC-Thalamus Circuits in Depression, AUD, and ADHDRoom 103-104 -
Depression, alcohol use disorder (AUD), and ADHD share a core vulnerability: maladaptive synaptic plasticity and circuit dysfunction within prefrontal-thalamic-limbic networks. This symposium bridges fundamental synapse biology with clinically relevant brain disorders. Dr. Wang will open with an overview of the core mechanisms of synaptic plasticity that governs circuit function. Dr. Shin will discuss thalamohippocampal remodeling linking stress and chronic pain to affective dysregulation. Dr. Kang will present astrocyte-neuron interactions at tripartite synapses that drive alcohol withdrawal and comorbid anxiety. Dr. Oh will examine neuromodulatory control of prefrontal synapses, highlighting how early nicotine exposure may predispose individuals to ADHD-related circuit dysfunction.
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OrganizerWon Chan Oh (University of Colorado)
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ModeratorWon Chan Oh (University of Colorado)
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Speaker
Fundamental synaptic mechanisms of neural circuit dysfunction in disease
Jie Wang (The Hong Kong University of Science and Technology)
Thalamo-hippocampal circuit remodeling linking stress, chronic pain, and affective dysfunction
Sora Shin (Virginia Tech)
Astrocyte-neuron interactions at tripartite synapses in alcohol withdrawal and comorbid anxiety
Seungwoo Kang (University of Texas Health Science Center at Houston)
Neuromodulatory control of developing prefrontal synapses and vulnerability to ADHD
Won Chan Oh (University of Colorado)
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September 08 (Tue)
16:05-18:00Symposium 31. Hierarchical Organization of the Prefrontal Cortex in Goal-Directed BehaviorRoom 107-108 -
The mammalian cortex is organized hierarchically, with the prefrontal cortex (PFC) at its apex, integrating information across sensory, motor, and limbic domains. This symposium will explore how hierarchical processing in the PFC supports goal-directed behavior across species. By combining insights from rodent and human studies, the speakers will reveal convergent and divergent principles of prefrontal computation and control, offering a cross-species perspective on the neural mechanisms of adaptive behavior.
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OrganizerJong-Cheol Rah (Korea Brain Research Institute)
Seung-Hee Lee (Korea Advanced Institute of Science and Technology/Institute for Basic Science)
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ModeratorJong-Cheol Rah (Korea Brain Research Institute)
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Speaker
The organization of representations for hierarchical cognitive control
David Badre (Brown University)
Graded prefrontal-sensory connectivity underlies cross-modal hierarchical control
Hyeon-Ae Jeon (Seoul National University)
Adaptive feedback as a control mechanism for flexible learning
Abhishek Banerjee (University of Oxford)
Cortical circuits for executive control
Tsukasa Kamigaki (Nanyang Technological University)
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